IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1
Identifieur interne : 000764 ( Main/Exploration ); précédent : 000763; suivant : 000765IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1
Auteurs : K. D. Hebert [États-Unis] ; N. Mclaughlin [États-Unis] ; Zhe Zhang [États-Unis] ; A. Cipriani [États-Unis] ; J. F. Alcorn [États-Unis] ; D. A. Pociask [États-Unis]Source :
- Respiratory Research [ 1465-9921 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Cellules A549, Chloroquine (pharmacologie), Facteur de transcription STAT-1 (biosynthèse), Grippe humaine (anatomopathologie), Grippe humaine (métabolisme), Humains, Interférons (pharmacologie), Mâle, Poly I-C (pharmacologie), Récepteur de type Toll-3 (biosynthèse), Récepteurs aux interleukines (biosynthèse), Souris, Souris de lignée C57BL.
- MESH :
- anatomopathologie : Grippe humaine.
- biosynthèse : Facteur de transcription STAT-1, Récepteur de type Toll-3, Récepteurs aux interleukines.
- métabolisme : Grippe humaine.
- pharmacologie : Chloroquine, Interférons, Poly I-C.
- Animaux, Cellules A549, Humains, Mâle, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- A549 Cells, Animals, Chloroquine (pharmacology), Humans, Influenza, Human (metabolism), Influenza, Human (pathology), Interferons (pharmacology), Male, Mice, Mice, Inbred C57BL, Poly I-C (pharmacology), Receptors, Interleukin (biosynthesis), STAT1 Transcription Factor (biosynthesis), Toll-Like Receptor 3 (biosynthesis).
- MESH :
- chemical , biosynthesis : Receptors, Interleukin, STAT1 Transcription Factor, Toll-Like Receptor 3.
- chemical , pharmacology : Chloroquine, Interferons, Poly I-C.
- metabolism : Influenza, Human.
- pathology : Influenza, Human.
- A549 Cells, Animals, Humans, Male, Mice, Mice, Inbred C57BL.
Abstract
Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for severe influenza pneumonia prioritize the need for the discovery of effective therapies. IL-22 is a cytokine that promotes tissue integrity and has strong promise as a treatment option. While research has been focused on the cytokine itself, there is limited understanding of the regulation of the IL-22 receptor (IL-22Ra1) at the epithelial surface during infection.
IL-22Ra1 levels were measured by qRT-PCR, western blot and immunofluorescence following H1N1 influenza infection (A/PR/8/34 H1N1) or synthetic TLR3 mimetic, Poly (I:C). Regulation of the receptor was determined using STAT inhibitors (STAT1, STAT3 and PanSTAT inhibitors), TLR3 inhibition, and neutralization of interferon alpha receptor 2 (IFNAR2). Significance was determined by a
Here we show both in vivo and in vitro that IL-22Ra1 was induced as early as 24 h after influenza (H1N1 PR8) infection. This induction was triggered by toll-like receptor 3 (TLR3) as a TLR3 mimetic [Poly (I:C)] also induced IL-22Ra1 and inhibition of endosomal formation required for TLR3 function inhibited this process. This upregulation was dependent upon IFNβ signaling through STAT1. Importantly, induction of IL-22Ra1 significantly increased IL-22 signaling as evidenced by pSTAT3 levels following IL-22 treatment.
Collectively, these data suggest epithelial cells may optimize the beneficial effects of IL-22 through the induction of the IL-22 receptor during viral infection in the lung.
Url:
DOI: 10.1186/s12931-019-1153-4
PubMed: 31416461
PubMed Central: 6694528
Affiliations:
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Cipriani</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9753 0008</institution-id><institution-id institution-id-type="GRID">grid.239553.b</institution-id><institution>Department of Pediatrics,</institution><institution>Children’s Hospital of Pittsburgh of UPMC, One Children’s Hospital Drive,</institution></institution-wrap>4401 Penn Ave, Pittsburgh, PA 15224 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>4401 Penn Ave, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Alcorn, J F" sort="Alcorn, J F" uniqKey="Alcorn J" first="J. F." last="Alcorn">J. F. 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Pociask</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2217 8588</institution-id><institution-id institution-id-type="GRID">grid.265219.b</institution-id><institution>Department of Medicine, Pulmonary Diseases, Critical Care & Environmental Medicine,</institution><institution>Tulane University School of Medicine,</institution></institution-wrap>1430 Tulane Ave. Mail code sl279, New Orleans, LA 70112 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>1430 Tulane Ave. Mail code sl279, New Orleans</wicri:cityArea></affiliation></author></analytic><series><title level="j">Respiratory Research</title><idno type="ISSN">1465-9921</idno><idno type="eISSN">1465-993X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Animals</term><term>Chloroquine (pharmacology)</term><term>Humans</term><term>Influenza, Human (metabolism)</term><term>Influenza, Human (pathology)</term><term>Interferons (pharmacology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Poly I-C (pharmacology)</term><term>Receptors, Interleukin (biosynthesis)</term><term>STAT1 Transcription Factor (biosynthesis)</term><term>Toll-Like Receptor 3 (biosynthesis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules A549</term><term>Chloroquine (pharmacologie)</term><term>Facteur de transcription STAT-1 (biosynthèse)</term><term>Grippe humaine (anatomopathologie)</term><term>Grippe humaine (métabolisme)</term><term>Humains</term><term>Interférons (pharmacologie)</term><term>Mâle</term><term>Poly I-C (pharmacologie)</term><term>Récepteur de type Toll-3 (biosynthèse)</term><term>Récepteurs aux interleukines (biosynthèse)</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, Interleukin</term><term>STAT1 Transcription Factor</term><term>Toll-Like Receptor 3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term><term>Interferons</term><term>Poly I-C</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Facteur de transcription STAT-1</term><term>Récepteur de type Toll-3</term><term>Récepteurs aux interleukines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term><term>Interférons</term><term>Poly I-C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Animals</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules A549</term><term>Humains</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for severe influenza pneumonia prioritize the need for the discovery of effective therapies. IL-22 is a cytokine that promotes tissue integrity and has strong promise as a treatment option. While research has been focused on the cytokine itself, there is limited understanding of the regulation of the IL-22 receptor (IL-22Ra1) at the epithelial surface during infection.</p></sec><sec><title>Methods</title><p id="Par2">IL-22Ra1 levels were measured by qRT-PCR, western blot and immunofluorescence following H1N1 influenza infection (A/PR/8/34 H1N1) or synthetic TLR3 mimetic, Poly (I:C). Regulation of the receptor was determined using STAT inhibitors (STAT1, STAT3 and PanSTAT inhibitors), TLR3 inhibition, and neutralization of interferon alpha receptor 2 (IFNAR2). Significance was determined by a <italic>p</italic>-value of greater than 0.05. Significance between two groups was measured using unpaired t-test and significance between more than two groups was measured using one-way ANOVA with Tukey Multiple Comparison Test.</p></sec><sec><title>Results</title><p id="Par3">Here we show both in vivo and in vitro that IL-22Ra1 was induced as early as 24 h after influenza (H1N1 PR8) infection. This induction was triggered by toll-like receptor 3 (TLR3) as a TLR3 mimetic [Poly (I:C)] also induced IL-22Ra1 and inhibition of endosomal formation required for TLR3 function inhibited this process. This upregulation was dependent upon IFNβ signaling through STAT1. Importantly, induction of IL-22Ra1 significantly increased IL-22 signaling as evidenced by pSTAT3 levels following IL-22 treatment.</p></sec><sec><title>Conclusion</title><p id="Par4">Collectively, these data suggest epithelial cells may optimize the beneficial effects of IL-22 through the induction of the IL-22 receptor during viral infection in the lung.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Roberson, Ec" uniqKey="Roberson E">EC Roberson</name></author><author><name sortKey="Tully, Je" uniqKey="Tully J">JE Tully</name></author><author><name sortKey="Guala, As" uniqKey="Guala A">AS Guala</name></author><author><name sortKey="Reiss, Jn" uniqKey="Reiss J">JN Reiss</name></author><author><name sortKey="Godburn, Ke" uniqKey="Godburn K">KE Godburn</name></author><author><name sortKey="Pociask, Da" uniqKey="Pociask D">DA Pociask</name></author><author><name sortKey="Alcorn, Jf" uniqKey="Alcorn J">JF Alcorn</name></author><author><name sortKey="Riches, Dw" uniqKey="Riches D">DW Riches</name></author><author><name sortKey="Dienz, O" uniqKey="Dienz O">O Dienz</name></author><author><name sortKey="Janssen Heininger, Ym" uniqKey="Janssen Heininger Y">YM Janssen-Heininger</name></author><author><name sortKey="Anathy, V" uniqKey="Anathy V">V Anathy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Short, Kr" uniqKey="Short K">KR Short</name></author><author><name sortKey="Kasper, J" uniqKey="Kasper J">J Kasper</name></author><author><name sortKey="Van Der Aa, S" uniqKey="Van Der Aa S">S van der Aa</name></author><author><name sortKey="Andeweg, Ac" uniqKey="Andeweg A">AC Andeweg</name></author><author><name sortKey="Zaaraoui Boutahar, F" uniqKey="Zaaraoui Boutahar F">F Zaaraoui-Boutahar</name></author><author><name sortKey="Goeijenbier, M" uniqKey="Goeijenbier M">M Goeijenbier</name></author><author><name sortKey="Richard, M" uniqKey="Richard M">M Richard</name></author><author><name sortKey="Herold, S" uniqKey="Herold S">S Herold</name></author><author><name sortKey="Becker, C" uniqKey="Becker C">C Becker</name></author><author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwig, S" uniqKey="Ludwig S">S Ludwig</name></author><author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S Pleschka</name></author><author><name sortKey="Planz, O" uniqKey="Planz O">O Planz</name></author><author><name sortKey="Wolff, T" uniqKey="Wolff T">T Wolff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Goraya, Mu" uniqKey="Goraya M">MU Goraya</name></author><author><name sortKey="Maarouf, M" uniqKey="Maarouf M">M Maarouf</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name></author><author><name sortKey="Chen, Jl" uniqKey="Chen J">JL Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovach, Ma" uniqKey="Kovach M">MA Kovach</name></author><author><name sortKey="Standiford, Tj" uniqKey="Standiford T">TJ Standiford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M Matsumoto</name></author><author><name sortKey="Oshiumi, H" uniqKey="Oshiumi H">H Oshiumi</name></author><author><name sortKey="Seya, T" uniqKey="Seya T">T Seya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonjardim, Ca" uniqKey="Bonjardim C">CA Bonjardim</name></author><author><name sortKey="Ferreira, Pcp" uniqKey="Ferreira P">PCP Ferreira</name></author><author><name sortKey="Kroon, Eg" uniqKey="Kroon E">EG Kroon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotenko, Sv" uniqKey="Kotenko S">SV Kotenko</name></author><author><name sortKey="Izotova, Ls" uniqKey="Izotova L">LS Izotova</name></author><author><name sortKey="Mirochnitchenko, Ov" uniqKey="Mirochnitchenko O">OV Mirochnitchenko</name></author><author><name sortKey="Esterova, E" uniqKey="Esterova E">E 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Alcorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dugger, Dt" uniqKey="Dugger D">DT Dugger</name></author><author><name sortKey="Gerriets, Je" uniqKey="Gerriets J">JE Gerriets</name></author><author><name sortKey="Miller, La" uniqKey="Miller L">LA Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pociask, Da" uniqKey="Pociask D">DA Pociask</name></author><author><name sortKey="Robinson, Km" uniqKey="Robinson K">KM Robinson</name></author><author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name></author><author><name sortKey="Mchugh, Kj" uniqKey="Mchugh K">KJ McHugh</name></author><author><name sortKey="Clay, Me" uniqKey="Clay M">ME Clay</name></author><author><name sortKey="Huang, Gt" uniqKey="Huang G">GT Huang</name></author><author><name sortKey="Benos, Pv" uniqKey="Benos P">PV Benos</name></author><author><name sortKey="Janssen Heininger, Ymw" uniqKey="Janssen Heininger Y">YMW Janssen-Heininger</name></author><author><name sortKey="Kolls, Jk" uniqKey="Kolls J">JK Kolls</name></author><author><name sortKey="Anathy, V" uniqKey="Anathy V">V Anathy</name></author><author><name sortKey="Alcorn, Jf" uniqKey="Alcorn J">JF Alcorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siemens, N" uniqKey="Siemens N">N Siemens</name></author><author><name sortKey="Oehmcke Hecht, S" uniqKey="Oehmcke Hecht S">S Oehmcke-Hecht</name></author><author><name sortKey="Mettenleiter, Tc" uniqKey="Mettenleiter T">TC Mettenleiter</name></author><author><name sortKey="Kreikemeyer, B" uniqKey="Kreikemeyer B">B Kreikemeyer</name></author><author><name sortKey="Valentin Weigand, P" uniqKey="Valentin Weigand P">P Valentin-Weigand</name></author><author><name sortKey="Hammerschmidt, S" uniqKey="Hammerschmidt S">S Hammerschmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Sc" uniqKey="Liang S">SC Liang</name></author><author><name sortKey="Tan, Xy" uniqKey="Tan X">XY Tan</name></author><author><name sortKey="Luxenberg, Dp" uniqKey="Luxenberg D">DP Luxenberg</name></author><author><name sortKey="Karim, R" uniqKey="Karim R">R Karim</name></author><author><name sortKey="Dunussi Joannopoulos, K" uniqKey="Dunussi Joannopoulos K">K Dunussi-Joannopoulos</name></author><author><name sortKey="Collins, M" uniqKey="Collins M">M Collins</name></author><author><name sortKey="Fouser, La" uniqKey="Fouser L">LA Fouser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aujla, Sj" uniqKey="Aujla S">SJ Aujla</name></author><author><name sortKey="Chan, Yr" uniqKey="Chan Y">YR Chan</name></author><author><name sortKey="Zheng, M" uniqKey="Zheng M">M Zheng</name></author><author><name sortKey="Fei, M" uniqKey="Fei M">M Fei</name></author><author><name sortKey="Askew, Dj" uniqKey="Askew D">DJ Askew</name></author><author><name sortKey="Pociask, Da" uniqKey="Pociask D">DA Pociask</name></author><author><name sortKey="Reinhart, Ta" uniqKey="Reinhart T">TA Reinhart</name></author><author><name sortKey="Mcallister, F" uniqKey="Mcallister F">F McAllister</name></author><author><name sortKey="Edeal, J" uniqKey="Edeal J">J Edeal</name></author><author><name sortKey="Gaus, K" uniqKey="Gaus K">K Gaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gessner, Ma" uniqKey="Gessner M">MA Gessner</name></author><author><name sortKey="Werner, Jl" uniqKey="Werner J">JL Werner</name></author><author><name sortKey="Lilly, Lm" uniqKey="Lilly L">LM Lilly</name></author><author><name sortKey="Nelson, Mp" uniqKey="Nelson M">MP Nelson</name></author><author><name sortKey="Metz, Ae" uniqKey="Metz A">AE Metz</name></author><author><name sortKey="Dunaway, Cw" uniqKey="Dunaway C">CW Dunaway</name></author><author><name sortKey="Chan, Yr" uniqKey="Chan Y">YR Chan</name></author><author><name sortKey="Ouyang, W" uniqKey="Ouyang W">W Ouyang</name></author><author><name sortKey="Brown, Gd" uniqKey="Brown G">GD Brown</name></author><author><name sortKey="Weaver, Ct" uniqKey="Weaver C">CT Weaver</name></author><author><name sortKey="Steele, C" uniqKey="Steele C">C Steele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paget, C" uniqKey="Paget C">C Paget</name></author><author><name sortKey="Ivanov, S" uniqKey="Ivanov S">S Ivanov</name></author><author><name sortKey="Fontaine, J" uniqKey="Fontaine J">J Fontaine</name></author><author><name sortKey="Renneson, J" uniqKey="Renneson J">J Renneson</name></author><author><name sortKey="Blanc, F" uniqKey="Blanc F">F Blanc</name></author><author><name sortKey="Pichavant, M" uniqKey="Pichavant M">M Pichavant</name></author><author><name sortKey="Dumoutier, L" uniqKey="Dumoutier L">L Dumoutier</name></author><author><name sortKey="Ryffel, B" uniqKey="Ryffel B">B Ryffel</name></author><author><name sortKey="Renauld, Jc" uniqKey="Renauld J">JC Renauld</name></author><author><name sortKey="Gosset, P" uniqKey="Gosset P">P Gosset</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author><author><name sortKey="Danilenko, Dm" uniqKey="Danilenko D">DM Danilenko</name></author><author><name sortKey="Valdez, P" uniqKey="Valdez P">P Valdez</name></author><author><name sortKey="Kasman, I" uniqKey="Kasman I">I Kasman</name></author><author><name sortKey="Eastham Anderson, J" uniqKey="Eastham Anderson J">J Eastham-Anderson</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Ouyang, W" uniqKey="Ouyang W">W Ouyang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, R" uniqKey="Jiang R">R Jiang</name></author><author><name sortKey="Zhao, Cm" uniqKey="Zhao C">CM Zhao</name></author><author><name sortKey="Gao, Bb" uniqKey="Gao B">BB Gao</name></author><author><name sortKey="Shao, N" uniqKey="Shao N">N Shao</name></author><author><name sortKey="Wang, Sx" uniqKey="Wang S">SX Wang</name></author><author><name sortKey="Song, W" uniqKey="Song W">W Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voigt, C" uniqKey="Voigt C">C Voigt</name></author><author><name sortKey="May, P" uniqKey="May P">P May</name></author><author><name sortKey="Gottschlich, A" uniqKey="Gottschlich A">A Gottschlich</name></author><author><name sortKey="Markota, A" uniqKey="Markota A">A Markota</name></author><author><name sortKey="Wenk, D" uniqKey="Wenk D">D Wenk</name></author><author><name sortKey="Gerlach, I" uniqKey="Gerlach I">I Gerlach</name></author><author><name sortKey="Voigt, S" uniqKey="Voigt S">S Voigt</name></author><author><name sortKey="Stathopoulos, Gt" uniqKey="Stathopoulos G">GT Stathopoulos</name></author><author><name sortKey="Arendt, Kam" uniqKey="Arendt K">KAM Arendt</name></author><author><name sortKey="Heise, C" uniqKey="Heise C">C Heise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name></author><author><name sortKey="Thakar, Ms" uniqKey="Thakar M">MS Thakar</name></author><author><name sortKey="Ouyang, W" uniqKey="Ouyang W">W Ouyang</name></author><author><name sortKey="Malarkannan, S" uniqKey="Malarkannan S">S Malarkannan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotenko, Sv" uniqKey="Kotenko S">SV Kotenko</name></author><author><name sortKey="Izotova, Ls" uniqKey="Izotova L">LS Izotova</name></author><author><name sortKey="Mirochnitchenko, Ov" uniqKey="Mirochnitchenko O">OV Mirochnitchenko</name></author><author><name sortKey="Esterova, E" uniqKey="Esterova E">E Esterova</name></author><author><name sortKey="Dickensheets, H" uniqKey="Dickensheets H">H Dickensheets</name></author><author><name sortKey="Donnelly, Rp" uniqKey="Donnelly R">RP Donnelly</name></author><author><name sortKey="Pestka, S" uniqKey="Pestka S">S Pestka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Jcj" uniqKey="Martin J">JCJ Martin</name></author><author><name sortKey="Beriou, G" uniqKey="Beriou G">G Beriou</name></author><author><name sortKey="Heslan, M" uniqKey="Heslan M">M Heslan</name></author><author><name sortKey="Chauvin, C" uniqKey="Chauvin C">C Chauvin</name></author><author><name sortKey="Utriainen, L" uniqKey="Utriainen L">L Utriainen</name></author><author><name sortKey="Aumeunier, A" uniqKey="Aumeunier A">A Aumeunier</name></author><author><name sortKey="Scott, Cl" uniqKey="Scott C">CL Scott</name></author><author><name sortKey="Mowat, A" uniqKey="Mowat A">A Mowat</name></author><author><name sortKey="Cerovic, V" uniqKey="Cerovic V">V Cerovic</name></author><author><name sortKey="Houston, Sa" uniqKey="Houston S">SA Houston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Jc" uniqKey="Martin J">JC Martin</name></author><author><name sortKey="Wolk, K" uniqKey="Wolk K">K Wolk</name></author><author><name sortKey="Beriou, G" uniqKey="Beriou G">G Beriou</name></author><author><name sortKey="Abidi, A" uniqKey="Abidi A">A Abidi</name></author><author><name sortKey="Witte Handel, E" uniqKey="Witte Handel E">E Witte-Handel</name></author><author><name sortKey="Louvet, C" uniqKey="Louvet C">C Louvet</name></author><author><name sortKey="Kokolakis, G" uniqKey="Kokolakis G">G Kokolakis</name></author><author><name sortKey="Drujont, L" uniqKey="Drujont L">L Drujont</name></author><author><name sortKey="Dumoutier, L" uniqKey="Dumoutier L">L Dumoutier</name></author><author><name sortKey="Renauld, Jc" uniqKey="Renauld J">JC Renauld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemaire, Mm" uniqKey="Lemaire M">MM Lemaire</name></author><author><name sortKey="Vanhaudenarde, A" uniqKey="Vanhaudenarde A">A Vanhaudenarde</name></author><author><name sortKey="Nizet, Y" uniqKey="Nizet Y">Y Nizet</name></author><author><name sortKey="Dumoutier, L" uniqKey="Dumoutier L">L Dumoutier</name></author><author><name sortKey="Renauld, Jc" uniqKey="Renauld J">JC Renauld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tachiiri, A" uniqKey="Tachiiri A">A Tachiiri</name></author><author><name sortKey="Imamura, R" uniqKey="Imamura R">R Imamura</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Fukui, M" uniqKey="Fukui M">M Fukui</name></author><author><name sortKey="Umemura, M" uniqKey="Umemura M">M Umemura</name></author><author><name sortKey="Suda, T" uniqKey="Suda T">T Suda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerlach, Rl" uniqKey="Gerlach R">RL Gerlach</name></author><author><name sortKey="Camp, Jv" uniqKey="Camp J">JV Camp</name></author><author><name sortKey="Chu, Yk" uniqKey="Chu Y">YK Chu</name></author><author><name sortKey="Jonsson, Cb" uniqKey="Jonsson C">CB Jonsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapira, Sd" uniqKey="Shapira S">SD Shapira</name></author><author><name sortKey="Gat Viks, I" uniqKey="Gat Viks I">I Gat-Viks</name></author><author><name sortKey="Shum, Bo" uniqKey="Shum B">BO Shum</name></author><author><name sortKey="Dricot, A" uniqKey="Dricot A">A Dricot</name></author><author><name sortKey="De Grace, Mm" uniqKey="De Grace M">MM de Grace</name></author><author><name sortKey="Wu, L" uniqKey="Wu L">L Wu</name></author><author><name sortKey="Gupta, Pb" uniqKey="Gupta P">PB Gupta</name></author><author><name sortKey="Hao, T" uniqKey="Hao T">T Hao</name></author><author><name sortKey="Silver, Sj" uniqKey="Silver S">SJ Silver</name></author><author><name sortKey="Root, De" uniqKey="Root D">DE Root</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Wx" uniqKey="Wu W">WX Wu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Duggan, Es" uniqKey="Duggan E">ES Duggan</name></author><author><name sortKey="Booth, Jl" uniqKey="Booth J">JL Booth</name></author><author><name sortKey="Zou, Mh" uniqKey="Zou M">MH Zou</name></author><author><name sortKey="Metcalf, Jp" uniqKey="Metcalf J">JP Metcalf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perales Linares, R" uniqKey="Perales Linares R">R Perales-Linares</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doyle, S" uniqKey="Doyle S">S Doyle</name></author><author><name sortKey="Vaidya, S" uniqKey="Vaidya S">S Vaidya</name></author><author><name sortKey="O Connell, R" uniqKey="O Connell R">R O'Connell</name></author><author><name sortKey="Dadgostar, H" uniqKey="Dadgostar H">H Dadgostar</name></author><author><name sortKey="Dempsey, P" uniqKey="Dempsey P">P Dempsey</name></author><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name></author><author><name sortKey="Rao, G" uniqKey="Rao G">G Rao</name></author><author><name sortKey="Sun, R" uniqKey="Sun R">R Sun</name></author><author><name sortKey="Haberland, M" uniqKey="Haberland M">M Haberland</name></author><author><name sortKey="Modlin, R" uniqKey="Modlin R">R Modlin</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Su, J" uniqKey="Su J">J Su</name></author><author><name sortKey="Peppelenbosch, Mp" uniqKey="Peppelenbosch M">MP Peppelenbosch</name></author><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreos, R" uniqKey="Dreos R">R Dreos</name></author><author><name sortKey="Ambrosini, G" uniqKey="Ambrosini G">G Ambrosini</name></author><author><name sortKey="Perier, Rc" uniqKey="Perier R">RC Perier</name></author><author><name sortKey="Bucher, P" uniqKey="Bucher P">P Bucher</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Louisiane</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Louisiane"><name sortKey="Hebert, K D" sort="Hebert, K D" uniqKey="Hebert K" first="K. D." last="Hebert">K. D. Hebert</name></region><name sortKey="Alcorn, J F" sort="Alcorn, J F" uniqKey="Alcorn J" first="J. F." last="Alcorn">J. F. Alcorn</name><name sortKey="Cipriani, A" sort="Cipriani, A" uniqKey="Cipriani A" first="A." last="Cipriani">A. Cipriani</name><name sortKey="Mclaughlin, N" sort="Mclaughlin, N" uniqKey="Mclaughlin N" first="N." last="Mclaughlin">N. Mclaughlin</name><name sortKey="Pociask, D A" sort="Pociask, D A" uniqKey="Pociask D" first="D. A." last="Pociask">D. A. Pociask</name><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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